Mouse anti-IL-1 RII, clone 6G5 - 1 mL

Description :The antibody reacts specificly with Human IL-1RII. The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Applications :ELISA Species_reactivity :human Clone :6G5 Clonality :Monoclonal Storage_Buffer :PBS with 0.1% BSA and 0.02% sodium azide Concentration :100 ug/ ml References(General) :(1) Mantovani; A et al. Ann N Y Acad Sci 1998; 840: 338 (2) Penton-Rol, G et al J Immunol 1999, 162: 2931 (3) Muller; B et al. J Leukoc Biol 2002; 72: 643