Mouse anti-p27, clone SX53G8 - 7 mL

Description :P27, also known as cyclin-dependent kinase inhibitor 1B (CDNK1B), is a kinase inhibitor that controls cell cycle progression.1-4 p27 is involved in G1 phase arrest and obstructs cell entry into the S phase by binding to and inhibiting cyclin E-CDK2, effectively slowing or stopping the cell division cycle.1-4 p27 is broadly expressed in normal tissue but can be dysfunctional in neoplastic tissue and, therefore, not expressed. Applications :IHC-P Species_reactivity :human Clone :SX53G8 Clonality :Monoclonal Storage_Buffer :Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide References(General) :(1) Polyak K, et al. Cell. 1994; 78:59-66 (2) Sun C, et al. AM J Cancer Res. 2016; 6:2207-20 (3) Sangfelt O, et al. Oncogene. 1999; 18:2798-810 (4) Hsieh FF, et al. Blood. 2000; 96:2746-54 (5) Migita, Toshiro et al. Cancer 2002; 94; 973-9