CDKN1A Polyclonal Antibody, FITC Conjugated - 100 µL

Alternate_names :P21 Description :May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyc lin D-CDK4 complex (By similarity). Applications :WB | IHC-P | IHC | ICC Species_reactivity :Human, Mouse, Rat, Sheep Clonality :Polyclonal Storage_Buffer :Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Concentration :1ug/ul